Nanoparticles (NPs) hold significant potential in the field of nanomedicine, serving as a primary focus of research for the development of innovative solutions to the limitations of conventional pharmaceuticals. Within this field, a diverse array of nanoplatforms has been developed and utilized, particularly in cancer treatment, including inorganic, lipid-based, and engineered biomimetic nanoparticles. These advancements have facilitated the creation of more specific, efficient, and safer therapeutic strategies, thereby contributing to the ongoing progress of personalized medicine. All these systems are designed with a specific biomedical purpose. However, once administered, NPs interact with the biological environment, initiating a dynamic process in which circulating biomolecules, mainly proteins, adsorb and desorb from the NP surface.