Matteo Nicolo
Characterization of a collagen-based hydrogel crosslinked with biofunctional polyphenols.
Rel. Silvia Spriano, Sara Ferraris. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
Abstract
Osteoarthritis (OA) is a degenerative joint disease caused by numerous factors marked by cell stress, inflammation and joint damage, which unlike other conditions does not resolve on its own and causes chronic pain and loss of function, especially in older adults. The loss of autonomy and productivity, caused by OA, together with direct medical costs related to its treatment have significant social and economic impacts. The fact that current treatments only address symptoms without halting disease progress, with extensive surgery as a last resort, highlights the need for new form of treatment focused on stopping joint degeneration and restoring joint function to improve patient outcomes.
Hydrogels are being explored as a promising treatment for OA, acting as a delivery system for drugs, biochemical signals and cells, to slow down joint degeneration and support cartilage regeneration
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