The bicuspid aortic valve (BAV) is among the most prevalent congenital heart disorders, affecting approximately 1-2% of the population. This condition is often associated with an increased risk of cardiovascular complications, including thoracic aortic aneurysms (TAAs), which are significant risk factors for severe events such as aortic dissection or rupture. The mechanisms behind TAA progression and rupture remain unclear and current guidelines primarily rely on maximum aortic diameter (>5.5 cm) as the main predictor for surgical intervention and monitoring, a parameter which is limited in effectiveness. This limitation underscores the need to investigate further biological and biomechanical factors and their role in these pathologies.