Giulia Guastavino
4D Flow MRI-based study of helical blood flow patterns in healthy and diseased thoracic aortas.
Rel. Karol Calo', Umberto Morbiducci, Valentina Mazzi. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
Abstract
One of the most prevalent congenital heart defects is the bicuspid aortic valve (BAV), which is frequently linked to dangerous side effects, notably thoracic aortic dilatation. Aortic dilatations can progress into aneurysms, which are typically not detected early and may not show symptoms until they reach a critical size or rupture, leading to unforeseen and fatal outcomes. The current standard clinical assessment of the risk of rupture based only on the aneurysm's diameter is insufficient, as evidenced by numerous studies. To improve current risk assessment, recent studies have investigated the role of hemodynamics in the progression of the abovementioned aortic diseases.
The aim of the study is to examine in vivo helical flow in the thoracic aorta and to explore its characteristics in both healthy individuals and in patients with a bicuspid aortic valve (BAV) and thoracic aortic dilatation (DIL)
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