Acetic acid is one of the most widely used carboxylic acid, with applications in textile, fibre, pharma and food industries. Nowadays, the majority of this chemical is produced via energy-intensive and fossil fuel-based processes, contributing to greenhouse gas emissions and environmental pollution. As a consequence, interest in the production of bio-acetic acid is growing. A promising route could be gas fermentation using CO2 and H2 as gaseous substrates. This path could potentially overcome the limits associated to sugar fermentation, i.e. the competition with food production and deforestation associated with first-generation biomass and the expensive pretreatment linked to second-generation one. Although CO2 fermentation is already practiced at an industrial scale for ethanol production, to the best of our knowledge scientific literature lacks any techno-economic analyses focused on the manufacture of acetic acid through the same approach.