Silvia Pisani
Towards the complete automatization of BBCT-hip in silico methodology for femur fracture risk prediction.
Rel. Alessandra Aldieri, Massimiliano Mercuri. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
Abstract
Femoral fractures are common in the elderly, primarily due to age-related osteoporosis and the increased risk of falls. Recently, in silico methodologies have gained significant attention for predicting fracture risk, particularly in the context of osteoporosis management. To be effective in clinical settings, they require automatization, which reduces analysis time, enhances accessibility through hospital system integration, and standardizes results for consistency regardless of operator experience. In this context, this study presents a practical application of a novel in-silico methodology, the Bologna Biomechanical Computed Tomography at the hip (BBCT-hip), which integrates patient-specific Finite Element (FE) simulations and a stochastic mathematical model to predict the femoral absolute risk of fractures at time 0 (ARF0).
The aim of this work was specifically to focus on the automatization of two central steps of the BBCT-hip process: the segmentation procedure, which derives the femur geometry from CT scan, and the material mapping phase, which is based on the CT Hounsfield Unit
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