Silvia Casari
Development of a 3D in vitro Model of Spinal Cord Injury Using Additive Manufacturing Technologies.
Rel. Chiara Tonda Turo, Gianluca Ciardelli. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
Abstract
Spinal cord injury (SCI) is a disabling pathology that occurs in the spinal cord (SC) following traumatic events such as accidents or falls, or non-traumatic causes such as tumors or infections. The primary phase, corresponding to the initial injury, is followed by a secondary acute-to-chronic inflammatory phase that can last for months and is characterized by neuronal and glial cell death, resulting in glial scar formation that hinders recovery. Once the inflammatory phases are complete, the result is a sensory and/or motor paralysis which can affect only the trunk and legs (paraplegia) or arms, body and legs (tetraplegia). The World Health Organization reports that SCI incurs significant lifetime costs, due to medical care and loss of productivity.
Today, there is no efficient therapy for SCI, mainly because many of the inflammatory mechanisms that occur after injury are not fully understood
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