Cardiovascular diseases (CVD) are the leading cause of death in the United States, claiming a life every 33 seconds. In 2021, CVD accounted for approximately 695,000 deaths, underscoring the urgent need for enhanced preventive and therapeutic strategies. Globally, the challenge of CVD continues to grow, with 19.05 million deaths in 2020, highlighting the escalating burden of cardiovascular diseases. Heart diseases, particularly valvular diseases, play a significant role in global health issues, especially among the elderly population. Valvular conditions, such as aortic stenosis, are prevalent and complex, disrupting critical cardiovascular functions. Aortic stenosis, primarily caused by age-related calcification of the aortic valve, restricts blood flow from the left ventricle to the aorta.