Elastic Network Models (ENMs) are a family of methods used to investigate the dynamic comportment of the proteins. These models use structural mechanics concepts to describe the conformational changes of proteins. The simple idea behind them is that a protein can be described as a set of particles connected by springs. The atoms are point masses while the interaction between them is modelled as springs. These models used in combination with normal mode analysis (NMA) describe protein’s intrinsic flexibility to study functional motions of proteins, to analyse transition pathway, and to investigate molecular docking mechanism. It is interesting to investigate the change in the dynamics of a protein because it is strictly related to the biological function of the protein.