Lung cancer is one of the most diagnosed and deadly cancer worldwide. It is classified in two main groups according to the cell of origin and histopathological properties: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). The focus of this thesis is put on the most common subtype of NSCLC, the adenocarcinoma (ADC), which grown in the alveoli from type 2 pneumocytes, the epithelial cells involved in interstitial mucus production. Beyond tumor cells, the aggressiveness of ADC is linked to the microenvironment which mainly consists in the extracellular matrix (ECM), which provides mechanical and biological support to the cellular components of the stroma.