Matteo Felice Pezzuto
Hybrid organic/metal nanoparticles for photothermal treatment of chronic wounds.
Rel. Gianluca Ciardelli, Clara Mattu, Monica Boffito, Giulia Crivello. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
Abstract
Chronic wounds (CWs) are a pathological condition in which an injured tissue fails to restore its anatomic and functional integrity. The normal wound healing process can be affected by several factors, including imbalance of reactive oxygen species, up-regulation of metalloproteinases (MMPs), bacterial infections, and bacteria biofilms, the latter representing a substantial obstacle to wound healing. This thesis aimed at developing lignin (Lig) cobalt-phthalocyanine (CoPc) nanoparticles (NPs) able to restore healing in infected chronic wounds. Lig was conjugated with tannic acid to achieve antioxidant and MMP inhibition properties. CoPc, a complex combining photo-excitable Pc with antimicrobial Co, was selected to provide antibacterial activity and biofilm eradication through photothermal action.
Different NPs formulations with varying amounts of CoPc and Lig were synthesized and characterized
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