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Design and development of viscoelastic and electroconductive hydrogels for in vitro models of cardiac tissue

Carlotta Ricciardi

Design and development of viscoelastic and electroconductive hydrogels for in vitro models of cardiac tissue.

Rel. Valeria Chiono, Elena Marcello, Daniele Testore, Camilla Paoletti. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024

Abstract:

Myocardial infarction is a major cause of death worldwide. Cardiac tissue engineering (CTE) offers biomaterial-based strategies to restore cardiac function and develop in vitro models for drug discovery. Biomimetic 3D hydrogels reproducing ECM-like viscoelasticity and electroconductivity are crucial for cell regulation and maturation. This thesis was aimed at the optimization of previously formulated click-chemistry based double cross-linked hydrogels . Particularly, the addition of an electroconductive filler was investigated, as well as the biological validation of hydrogels for the in vitro modeling of cardiac tissue.

Relators: Valeria Chiono, Elena Marcello, Daniele Testore, Camilla Paoletti
Academic year: 2023/24
Publication type: Electronic
Number of Pages: 80
Additional Information: Tesi secretata. Fulltext non presente
Subjects:
Corso di laurea: Corso di laurea magistrale in Ingegneria Biomedica
Classe di laurea: New organization > Master science > LM-21 - BIOMEDICAL ENGINEERING
Aziende collaboratrici: Politecnico di Torino
URI: http://webthesis.biblio.polito.it/id/eprint/32099
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