In today's world, cancer stands as a primary cause of death in the most developed nations, with projected increases in mortality rates in the years ahead. Hence, there is an urgent need to enhance research efforts in developing anti-cancer drugs. This study aims on refining the process of screening anti-cancer drugs. It involves immobilizing the enzyme Lactate Dehydrogenase (LDH) on mesoporous silica supports to create an enzyme-based device capable of efficiently testing potential anti-cancer drugs by assessing their ability to inhibit enzyme activity. The enzyme was immobilized on SBA-15 and functionalized using two different organosilanes, APTES and GPTMS. Various ratios of these organosilanes (3:1, 1:1, 1:3) were tested to identify the optimal combination that maximizes biocatalyst activity.