Michela Rocchetti
A computational study of visual evoked potentials dynamics in dementia with a mesoscale brain model.
Rel. Andrea Antonio Gamba, Alberto Mazzoni. Politecnico di Torino, Corso di laurea magistrale in Physics Of Complex Systems (Fisica Dei Sistemi Complessi), 2024
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Abstract
The main goal of my work is to replicate the results obtained from an experimental setup. In this experiment, individuals from three different categories, namely healthy subjects (HS), subjective cognitive decline (SCD), and mild cognitive impairment (MCI), were asked to perform a visual attention task. Here different geometrical figures were displayed and the corresponding electrophysiological response to the stimulus, event-related potentials (ERPs), were recorded. The analysis of EEG data, coming from channels in correspondence of the visual cortex, revealed alterations in visual evoked potentials (VEPs) which correspond to the first physiological response to the stimulus and that are nonlinear with the worsening of the cases considered.
To be specific, the negative N1 component of the evoked potential, having its minimum after 80-120 ms from the onset of the stimuli, was found to be more pronounced in the CTR case, but less pronounced in SCD compared to in MCI
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