Colorectal cancer (CRC) is one of the oncological malignancies with the highest incidence and mortality rates. The dominant cause for such a high death rate is at large associated to the development of metastatic diseases. Statistics indeed show that about 25% of CRC patients is already affected by metastasis in the moment of the primary tumor diagnosis and almost the 50% of the cases evolve towards the same direction. Several studies noticed that Extracellular Vesicles (EVs) secreted by CRC cells carry intercellular signals and promote the tumor cells colonization of distant organ-specific metastatic sites, like liver and lungs. In particular, tumor cells produce a much greater amount of vesicles than healthy cells, allowing significant cell-cell exchanges, since they carry with them incorporated proteins, DNA, mRNA and microRNAs.