Within increasingly competitive and demanding requirements in terms of efficiency, performance, and costs, a constant effort to optimize analysis and production processes is indispensable in order to meet internal, market, and customer demands. It becomes essential to reduce margins of uncertainty to provide clear answers. Unfortunately, in the realm of physical phenomena, high degrees of uncertainty are inherent to the phenomena themselves, prompting the search and the development of increasingly predictive models and methods to simulate phenomena in order to reduce any real event to a simulation easily replicable at a lower cost. A particular case is that of thermo-mechanical fatigue (TMF), a definition that includes a condition where we see a juxtaposition of thermal and mechanical loads.