Carotid arteries are responsible for blood supply to the head and the neck, including brain perfusion. At the neck level, the left and right common carotid arteries divide into an internal carotid artery and an external carotid artery, at the so called carotid bifurcation. The carotid bifurcation is particularly prone to the development of atherosclerotic plaques, which can cause relevant clinical events such as transient ischemic attacks and stroke. A vast body of literature has proven that the onset and progression of atherosclerosis at the carotid bifurcation is largely determined by the complex hemodynamic environment. In this context, the in silico investigation of carotid bifurcation hemodynamics can support the identification of atheroprone regions and the prediction of plaques development risk.