The rejection rate of heart transplant (HTx) remains considerably high despite recent medical advancements. The major cause of chronic rejection is cardiac allograft vasculopathy (CAV), a pathology that affects 50% of HTx recipients with a 32% 5-year mortality. CAV is triggered by a strong immune response of the host to the graft and it is characterized by neointimal formation in the coronary arteries, ultimately culminating in critical vessel occlusion and graft failure. Currently, no effective treatments or diagnostic biomarkers are available for CAV, mainly due to a poor understanding of the disease initiation mechanisms. The morphology of coronary arteries is believed to play an important role within CAV etiology and progression, and, consequently, within HTx long-term outcome.