Cecile Serenelli
Manufacturing and bioactivity assessment of 3D printed composite scaffolds for guided bone regeneration procedures.
Rel. Gianluca Ciardelli, Chiara Tonda Turo. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2024
Abstract
Alveolar bone fractures and periodontal diseases, above all periodontitis, are an increasing social, medical, and economic issue of the new millennium ending in 7.5 million annual new cases of dentoalveolar issues worldwide and a total €149.52B loss in Europe alone. The clinical attention is drawn to the formation of alveolar bone defects, generated after a tooth loss and the consequent bone resorption process. An alveolar ridge augmentation technique is then essential as the lack of quality and bone volume may cause a collapse in dental implant placement while attempting to restore the missing teeth. The traditional treatments suggest the use of grafts or bone-filling particulate materials but, despite being a great approach for the biocompatibility, these classical strategies lack in reproducibility, bioactivity, and biodegradable properties.
In this study, 3D printed multi-layers resorbable scaffolds for GBR procedures were fabricated with the Bioplotter system in 5 different composite biomaterial formulations designed to enhance the bone regeneration process with bioactive properties
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