The Mediterranean basin is widely recognized as a climate change hotspot, with climate models projecting increasingly warmer and drier conditions that will impact local ecosystems, communities, and economies. Agriculture will be among the most affected sectors, with harsher conditions for crops’ growth, greater water needs, and lower yields. One of the most resilient crops to limiting and stressful conditions is barley, which is often sown in areas where other crops and cereals would struggle. This work analyzed the impacts of climate change on rainfed barley using the province of Almeria as a case study. This is one of the most arid areas of the Mediterranean basin, where agriculture is among the main economic resources, and where barley is the main crop produced outside greenhouses.