3D printing is a cutting-edge technology that provides a variety of benefits including design flexibility and the opportunity to experiment with different non-conventional geometries. With this consideration, the main objective of this investigation is to design, simulate, and assess the thermal performance of clay 3D-printed prefabricated wall components. To accomplish this, a parametric and algorithmic approach was employed, and a comprehensive methodology was established, with the final aim of being validated, scaled, and replicated. It has been already proved that Additive Manufacturing (AM) technology has important advantages compared with traditional technologies since it represents an efficient and flexible, low-cost, energy and material-saving process, among many other positive characteristics.