According to the World Health Organization, cardiovascular diseases are the leading cause of death worldwide, causing a global burden of an estimated 17.9 million deaths. Cardiovascular functionality together with aging are strongly associated to changes in arterial pulse pressure and arterial stiffness. In fact, the latter is considered as a biomarker of cardiovascular risk, and the gold-standard non-invasive technique to assess it is through the pulse wave velocity (PWV), meaning the velocity of propagation of arterial blood pulse within the cardiovascular system. PWV is strongly related to both the biomechanical properties and the local hemodynamics developing within arteries, thus with the pathological mechanisms underlying cardiovascular diseases.