Alessio Arriku
A Network-based approach to investigate flow coherence alteration in coronary lesions at risk of myocardial infarction.
Rel. Karol Calo', Umberto Morbiducci, Maurizio Lodi Rizzini. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2023
Abstract
Many recent studies ascertained that cardiovascular diseases are in first place for cause of mortality worldwide. Atherosclerosis is a chronic and progressive pathology characterized by an initial deposit of lipids inside the inner layer (tunica intima) of an artery and it is the most prominent cardiovascular disease. As the fat accumulation progresses there is the creation of a plaque composed by a lipidic core and a thick fibrous cap. The growth of plaque causes an obstruction of the artery and consequently a drastic change in blood flow. If atherosclerosis affects coronary arteries, it leads to reduction in myocardial perfusion and may evolve in myocardial infarction (MI).
It has been widely demonstrated that a local disturbed hemodynamic environment, especially in terms of altered wall shear stress (WSS) features, can trigger a response of the endothelium characterized by uncontrolled intimal thickening with subsequent luminal narrowing (stenosis)
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