Sabrina Nocerino
Computational modelling of atherosclerotic coronary vessels with multi-layer material properties.
Rel. Diego Gallo, Sara Zambon, Maurizio Lodi Rizzini, Umberto Morbiducci. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2023
Abstract
Coronary arteries are a prominent site for atherosclerosis (AS), a chronic and progressive inflammatory condition characterized by arterial wall structural alterations. AS is a leading cause of fatalities and disabilities connected with cardiovascular diseases (CVD). Computational tools in coronary biomechanics investigate aspects not readily visible through imaging, such as wall shear stress (WSS) patterns and stress within coronary vasculature. While computational fluid dynamics (CFD) simulations have elucidated the role of WSS in the genesis and progression of coronary artery disease (CAD), they are constrained by the rigid-wall assumption, which is physiologically inaccurate. Conversely, fluid-structure interaction (FSI) methods account for vascular distensibility allowing for a more accurate representation of the healthy and/or altered mechanical properties of coronary wall.
Since the mechanical properties of solid domain are determinants for the computational assessment of stress distribution, this work focuses on coronary vessel wall materials, modeled with two levels of complexity
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