Francesco Antonio Mallus
Encoding Biomarkers of Consciousness Under Conditions of Abnormal Cortical Dynamics.
Rel. Valentina Agostini. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2023
Abstract
Consciousness and its absence can be assessed and quantified through different techniques. Sleep-stage classification via electroencephalography (EEG) signal analysis is the most common and effective method for this purpose. Recently, the research moved from a spectral investigation of the EEG to a complexity study. Entropy features showed to be more robust biomarkers of consciousness than frequency-based measures. To further contribute to this discussion, we utilized a Deep Learning (DL) derived function, Gradient-weighted Class Activation Mapping (Grad-CAM), to predict if this generalizability is found also in the DL's unbiased feature selection. To do so, we exploited a semi-automatic Machine Learning (ML) classification pipeline to compare the performances obtained with the original EEG and the Grad-CAM.
The generalizability of the identified features was addressed by using Angelman Syndrome (AS) patients as training set and Dup15q11.2-13.1 syndrome (Dup15q) patients as test set
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