The increasing global focus on hydrogen as a pivotal means to achieve decarbonization objectives prompts a critical inquiry into its future economic viability. Addressing this uncertainty necessitates using powerful analytical instruments, among which Energy System Optimization Models. Given the foundation of such models on the detailed techno-economic characterization of technologies composing the energy system, they are inherently data-driven and possibly subject to a notable degree of uncertainty concerning input parameters and, consequently, output results. For this reason, sensitivity analysis is commonly used to assess the robustness of the technology characterization. The objective of this thesis is to evaluate the sensitivity to some key parameters of the possible future hydrogen end-use technologies penetration in the energy system, according to alternative scenarios.