Following a discourse within the community of civil engineers in Italy sparked a debate about slab orientations. This dialogue emphasized the role of slab orientation as a potential factor in enhancing the cost-effectiveness and sustainability of structures in seismic regions. In response, CDM DOLMEN srl initiated an investigation to explore this hypothesis. Consequently, this thesis is dedicated to examining whether modifying the slab orientation indeed results in cost reduction while retaining safety. In reinforced concrete structures, slab orientation is an important design factor that may affect seismic resistance, cost effectiveness, and structural performance. The effects of various slab orientations on the cost-effectiveness and structural integrity of a built reinforced concrete structure situated in various seismic zones are thoroughly investigated in this thesis.