Davide Magliano
Use of a prostaglandin analog to improve blood flow and tendon regeneration in a rabbit model.
Rel. Danilo Demarchi, Carly Filgueira. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2023
Abstract
Tendon and ligament injuries account for 30% of all musculoskeletal consultations with 4 million new incidences worldwide each year. Current medical treatments, such as NSAIDS, Corticosteroids and injection of biologics and surgical remedies often fall short in restoring optimal tendon function, leading to elevated medical costs, prolonged recovery and significant productivity loss. Mature tendons are characterized by their dense structure and reduced vascularization, resulting in protracted healing times. Accelerating the healing process and enhancing regeneration can be achieved by augmenting blood circulation, thus facilitating the delivery of essential oxygen and nutrients while aiding in the clearance of fluid build-up. This research focuses on promoting patellar tendon repair by inducing vasodilation, using a localized injection of an FDA-approved small molecule drug in the knee to improve blood flow and accelerate regeneration.
In this 10 weeks in vivo study, we pursue two primary objectives with eight white New Zealand rabbits, divided into a control group and a study group, both subjected to a surgical procedure to induce a right patellar tendon injury
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