Daniel Andrea Mosca
MULTIFUNCTIONAL LAYER-BY-LAYER NANOCAPSULES LOADING DOCETAXEL, ENZALUTAMIDE, RESVERATROL AND DOXORUBICIN WITH ENHANCED TARGETING, IMAGING AND THERAPEUTIC EFFECTS AGAINST PROSTATE CANCER AND OSTEOSARCOMA.
Rel. Chiara Tonda Turo, Irene Carmagnola. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2023
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Abstract
The aim of this project was to develop a nanocarrier capsules to target tumours, especially prostate cancer and osteosarcoma. For the material the nanocore were thought to be made up by organic polymers such as Calcium, Phosphate. The nanocores alone were not able to target and deliver drugs due to their low size and chemical composition. For this reason, the layer-by-layer technique have been exploited in order to add specific properties upon surface of cores, avoiding changing the bulk their bulk properties. At the same time, also the layers have designed to be from natural compounds like Sodium alginate and Chitosan.
The chitosan is well-known to be one of the most exploited positive polyelectrolytes, it is acquired by modifying the chitin from sea animals
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