Pawat Akarapipattana
One-dimensional modeling of the self-assembly of complex elastic particles.
Rel. Alessandro Pelizzola, Martin Lenz. Politecnico di Torino, Corso di laurea magistrale in Physics Of Complex Systems (Fisica Dei Sistemi Complessi), 2023
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Abstract
Self-assembly is a spontaneous aggregation of small subunits into a larger structure. We focus on a specific kind of self-assembly phenomenon in cells where protein molecules aggregate into finite-size fibers. This phenomenon involves deformations and elastic properties of the protein molecules. However, this behavior has been shown to be generic beyond any specific types of proteins. Currently, the exact mathematical descriptions of the deformation are known only for a one-dimensional aggregate model consisting of simple subunits. Real-world protein molecules, on the other hand, pose more complexity -- both in terms of their shapes and their elastic properties -- and a more complex model is required.
In this work, we attempt to narrow down the difference between real-world systems and the existing mathematical models by introducing complexity via randomness of the positions of protein binding sites
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