The purpose of my thesis is to optimize and test a partially developed microfluidic platform with Organic Electrochemical Transistor (OECT) devices in order to detect specific biomarkers: tetracycline antibiotics and angiopoietin-2 (Ang2) protein. The protein detection is linked with the Digital tEchnology For Lung Cancer Treatment (DEFLeCT) project, targeting a biosensor for early diagnosis and treatment of lung cancer, through the detection of tumour biomarkers. The antibiotic detection instead has been funded by the Food Drug Free project, aiming at the detection of antibiotic traces in food samples, to fight the increasing issue of antibiotic resistance. Based on the technical improvements matured in these projects, this sensor will find an application in the new project, LoCNeuro, dedicated to the development of a lab-on-chip for monitoring neurodegenerative disorders associated with Covid-19 infection.