In recent years, several nanotools have been developed as effective therapeutic agents against cancer. These tools can be exploited for their intrinsic toxicity or they can be triggered by external stimuli of a different nature to cause cell death. Ultrasound (US) has emerged as a promising technique for the activation of specific nanomaterials, due to its deep tissue penetration and ability to focus in a specific area. This research work investigates the ultrasound response capacity of a specific nanocrystal. In particular, the system is formed by nanocrystals of zinc oxide, doped with iron atoms to increase the biocompatibility of the nanomaterial, functionalized with amino-propyl groups with the aim of improving the stability of the nanocrystals and increasing the gas pocket present on the surface of nanoparticles, which play an important role in the interaction with US.