Long-term exposure to pollutants and irritating agents may trigger the development of respiratory system infections and diseases, representing the second leading cause of death in the Western Word. Obstructive lung diseases, such as asthma, and chronic obstructive pulmonary disease are characterized by a reduction in bronchi lumen area, with consequent alteration of bronchial tree functionality. The main causes of obstructive diseases (ODs), often asymptomatic until significant lung damage has occurred, are still not completely understood. Studying the aerodynamics of the respiratory system might help the comprehension and characterization of the factors involved in ODs onset and development, supporting diagnosis, prediction and treatment evaluation.