Valentina Lucci
Modeling of peri-implant corneal tissues and simulation of their interaction with a new intracorneal implant for keratoconus correction.
Rel. Diego Gallo, Graziana Maria Ragonese, Dario Carbonaro, Claudio Chiastra. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2023
Abstract
Keratoconus is a progressive, non-inflammatory disease, characterized by stromal thinning and gradual protrusion of the cornea into a conical shape, resulting in irregular astigmatism and reduced visual acuity. Current treatment options available for the treatment of keratoconus suffer from major limitations, in particular Intra-Corneal Ring Segments (ICRS) offer scarce remodeling support to the cornea leading to unpredictable clinical results. The GROSSO® implant is the world's first nitinol corneal implant aiming at remodeling the whole cornea by virtue of a dome-shaped design. The mechanical performance of the GROSSO® implant was evaluated computationally in two potentially critical situations. The first situation consists of a 90° bending of two opposite edges of the implant occurring during its minimally invasive implantation in the patient's intracorneal pocket.
The second is a vertical crushing of the device to test its mechanical strength and provide information on possible impacts occurring in daily use
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