Molecular sorting is a fundamental ordering process taking place in eukaryotic cells, whereby proteins and other biomolecules are sorted and distilled into lipid vesicles. This process aims at countering the homoge- nizing effect of diffusion. Molecules attach to lipid membranes and later- ally diffuse, then due to a variety of direct and indirect interactions, these molecules tend to aggregate in domains characterized by specific chemical compositions. In their turn, such may promote membrane bending and fission, and are ultimately packed into lipid vesicles, that are then deliv- ered to appropriate intracellular destinations with the aid of molecular motors. This vesicles distillation phenomenon can be investigated from a physics perspective.