Battery systems play a vital role in numerous applications, ranging from electric vehicles to renewable energy storage. Accurate modelling and simulation of battery systems are crucial for assessing their lifetime performance. Currently, there are various simulation software on the market to assist industry and academia to implement multiphysics models and simulate battery systems. Every tool has unique capabilities, which can suit different user needs. This thesis investigates and compares four widely used multi-physics modelling and simulation software tools— Amesim, MATLAB/Simulink, MATLAB/Simulink/Simscape and Dymola—with respect to four main aspects, namely performance, ease of use, features, and licensing. The scope of the study is to highlight peculiarities of every software, to provide insights to simulation engineers, researchers and students that need to select the right simulation software for their investigations.