Space industry is experiencing a renewed interest in the Moon, its surface exploration, and the exploration of in-situ resources. In the near future, more and more missions will target Earth’s natural satellite, promoted by both governmental entities and commercial players. This upcoming growth of lunar activities will result in a considerable increase in data volume and information, which will need to be exchanged between assets on the Moon and Earth. Furthermore, the project of a stable and permanent presence of humans in the Moon environment involves the creation of a great number of services and facilities for future lunar inhabitants. The aim of this Thesis is the application of system engineering techniques to a real business case in order to acquire experience and knowledge in the space system design process.