In the context of human habitat inside the Lunar Gateway orbiting around the moon, this thesis has the aim of assessing the proposed ventilation system of the Private Crew Compartment, and evaluating its meeting of requirements in terms of thermal comfort and carbon dioxide concentration. Beginning with the stated architecture, the assessments have been carried out through a thermofluidic lumped parameter model that represents the pipeline ventilation system, providing the housing for astronauts with cool and fresh air. In order to build the model, the behavior of the elements has been extracted from the Idelchik’s manual and from the CFD analyses for two particular components: the wye fitting with its previous elements and the adapter from circular to flat section.