Jacopo Zattoni
Computational Search for A Cure Against Brain-Eating Amoeba.
Rel. Jacek Adam Tuszynski. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2023
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Abstract
Naegleria Fowleri is a thermophilic, free-living amoeba of the genus Naegleria. Also known as "brain-eating" amoeba, it is capable of infecting animals' and humans' nervous systems when contaminated water is inhaled. Upon reaching the brain, the amoeba digests the host’s nervous cells, provoking a condition called Primary Amoebic Meningoencephalitis (PAM): diffuse brain hemorrhage, inflammation and swelling, that impair the host’s cognitive abilities and eventually lead to its death within two weeks of the infection’s onset. The current treatment's efficacy is highly dependent on the speed of diagnosis, and is hampered by the low specificity of the drugs used as well as the need to cross the blood-brain barrier (BBB).
Together with the infection’s nonspecific symptoms, these aspects are responsible for the worryingly high mortality rate, above 95%
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