Giulia Nelli
Computational search for putative inhibitors of MAP-tau hyperphosphorylation in Alzheimer's disease.
Rel. Jacek Adam Tuszynski. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2023
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Abstract
Alzheimer's disease (AD), which has no known cure, is currently the most common neurodegenerative disease. Since the average age of the global population is constantly rising, AD is also recognized as one of the diseases with the quickest rate of growth. The loss of memory and executive functions is a hallmark of AD. This disease is characterized by aggregation of microtubule-associated protein tau and βamyloid peptides, which are components of neurofibrillary tangles (NFTs) and amyloid plaques, respectively. It has been demonstrated that one of the primary factors contributing to the development of AD is the aggregation of the microtubule-associated protein tau (MAPT), which was found to promote microtubule instability.
This aggregation originates from the hyperphosphorylation of protein tau, which reduces its ability to bind to microtubules
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