Renata Ricci Maga
Hemodynamic performance of current drug-eluting stents: a computational fluid dynamics study.
Rel. Claudio Chiastra, Giuseppe De Nisco. Politecnico di Torino, Master of science program in Biomedical Engineering, 2023
Abstract
Coronary arteries are particularly prone to the formation of atherosclerotic plaques, which may cause the narrowing of arterial lumen, and result in insufficient oxygen supply to the myocardium, or total occlusion of the vessel, with subsequent myocardial infarction. Nowadays, the most common non-surgical treatment for stenotic coronary arteries is percutaneous transluminal angioplasty with stent implantation. Stents are wide-mesh tubular metal nets that are inserted into the artery and expanded near the lesion to restore baseline blood flow. Although the use of stents is a well-established treatment for stenotic coronary arteries, its implantation modifies arterial geometry and local fluid dynamics, potentially leading to complications such as intra-stent restenosis or late stent thrombosis.
A large body of literature has demonstrated the association between these adverse events and the presence of altered local hemodynamics
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