Donatella Musaro'
Hemodynamic performance of open- and closed-cells coronary stents: a computational fluid dynamics idealized study.
Rel. Claudio Chiastra, Giuseppe De Nisco. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2023
Abstract
Coronary arteries can undergo progressive stiffening with loss of elasticity due to atherosclerosis. This pathological process consists in the accumulation of lipids at the arterial wall with the formation of an atherosclerotic plaque that may grow and narrow the arterial lumen, restricting blood flow to the myocardium. Nowadays, percutaneous coronary intervention (i.e., angioplasty with stent implantation) is the most common non-surgical treatment of narrowed coronary arteries. A stent is an expandable tubular structure made up of a mesh network that provides mechanical support to the vessel wall, restoring physiological conditions and ensuring proper blood flow to the heart. Several types of stents are commercially available and, based on composition, structure, and properties, are classified in three main families, namely (i) Bare Metal Stents, (ii) Drug Eluting Stents, and (iii) Bioabsorbable Stents.
Despite stent implantation has become increasingly popular in recent decades due to the effectiveness in preventing and treating cardiovascular disease, it alters the vessel geometry and generates a new local fluid dynamic environment, which may lead to future complications, such as in-stent restenosis or late stent thrombosis
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