The size and pulsatility of the inferior vena cava (IVC) allow the extraction of parameters that are difficult to estimate but essential for a correct diagnosis, such as the right atrial pressure or the blood volume status of patients. No standardized method exists for the analysis of this vessel. One of the most widely used techniques is M-mode ultrasound. However, this only allows the IVC scan to be viewed along a fixed direction and therefore cannot refer to the same section of the vessel as the vein moves during respiratory and cardiac activity. To overcome these limitations, a new software has been developed by Vein Image Processing for Edge Rendering (VIPER).