In the automotive industry, lightweight design is a consolidated trend. In order to accomplish the emissions targets, the use of aluminium alloys is a common choice among car manufacturers. This decision leads to the need of performing multi-material joints, implementing also new types of joining techniques. The Flow Drilling Screw process, also known by the acronym FDS, is a joining technique that consists in the use of a threaded fastener. The fastener has the task of plastically deforming the workpieces by creating a thread through which a clamping force is finally applied. The material is softened before the deformation by exploiting the heat generated by the friction between the workpieces and the fastener tip, which rotates at high rotational speed.