Chronic wounds (CWs) represent a major healthcare problem significantly affecting patient's quality of life. Despite the wide availability of commercial wound dressings, they are often ineffective in CW treatment due to the lack of patient personalization both in terms of in situ drug administration timing and shape. In this regard, this work aimed at overcoming such limiting issues by engineering a multifunctional ink with promising features for the fabrication of patient specific patches. More in detail, an amphiphilic poly(ether urethane) (PEU) (CHP407, Mn= 31kDa) was first synthesized by reacting Poloxamer 407, 1,6-diisocyanatohexane and 1,4-cyclohexanedimethanol. Then, CHP407 chains were functionalized with -COOH groups (P-CHP407) exploiting a green approach (i.e., plasma treatment with acrylic acid vapors) to provide the polymer with responsiveness to alkaline fluids.