Abdominal aortic aneurysm (AAA) is a pathological dilatation of the arterial wall, thus leading to its weakening and in many cases rupture, an event correlated with very high mortality rates. For this reason, the study of the pathogenesis, mechanisms of progression and subsequent rupture of AAAs is a very current topic of great clinical relevance. The biggest issue lies in the lack of a reliable parameter that can predict the risk of rupture of AAAs. Currently, the maximum diameter value is used as a threshold to define a AAA at high risk of rupture. Recent literature, however, has shown that this parameter alone cannot be considered a reliable predictor of rupture risk; in fact, some AAAs, despite reaching very large sizes, never rupture, while others with a small diameter, undergo premature rupture.