The paper is intended to analyse the impact of the REACH regulation on the competitiveness of chemical companies in the province of Alessandria. In particular, it aims to verify the applicability of Porter's hypothesis (1995) in the territorial context considered. This objective was achieved by conducting interviews involving professionals within the companies participating in the research. The legislation subject of the thesis is Regulation (EC) No. 1907/2006, known as REACH, which seeks, through the registration, evaluation and authorisation of substances, to ensure a higher level of protection of human health and the environment, while aspiring to maintain and strengthen the innovative capabilities and competitive position of the European chemical industry.