Lung cancer is one of the spreadest and deadliest disease within tumoral cases. In 2020 among all cancer types it was second in the number of diagnosed cases and first for the number of deaths. Today, although different new treatments have been set into the clinical strategies, improving the overall survival, the mortality is still high and further efforts are needed to improve the therapeutical effects of nowadays options. Recently, immunotherapy has gained interest incuring cancer disease and nowadays some treatment for lung cancer include antibodies. Another tested immuno-based therapy action are the cancer vaccines, which are used to help stimulate the immune system by transfecting specific anti-tumor antigen, leading to the regression of the tumoral mass by the bioengineering of the immunological cells within the tumoral environment.