This thesis aims to introduce the advantages of implementing cloud computing within a complex enterprise with a view to digital transformation. To achieve these advantages, technological, cultural, organizational changes as well as corporate roles and responsibilities following the adoption of the cloud have been described. The study is based on the identification of skills adaptation mechanisms by structuring a Cloud Center of Excellence (CCOE). The CCOE itself is being studied with particular focus on the ramp-up and steady state phases; in particular, it is highlighted that the team is initially temporary and then permeates within the organization leading to the definition of a new Cloud Target Operating Model.