Health diseases throughout history have brought cities’ design and infrastructures the challenge to improve and control the spread of the infectious virus. In the 19th century, the concern regarding promoting hygiene and healthy environments led to developing several urban design models and innovations. Urban planners such as Cerdà, Ebenezer Howard, Clarence Perry, and Le Corbusier were fundamental to the evolution of new urban approaches. In the 20th century, the World Health Organization started the movement known as Health Cities, which had as the main goal of promoting a healthy approach to environmental design. The debate on how to build a better urban environment is constantly under discussion, as the world’s circumstance keeps changing and has now been impacted by the COVID-19 pandemic.